NIPT Cyprus | NIPT Test in Cyprus, Appointment and Information

Q: What is NIPT and When is it Performed?

NIPT (Non-Invasive Prenatal Test) is an advanced screening test that analyzes cell-free fetal DNA in a blood sample taken from the mother. Since there is no direct intervention to the baby, it is non-invasive and different from amniocentesis. The test can be performed from the 10th week of pregnancy without requiring any special preparation or fasting. NIPT is a screening test; high-risk results must be confirmed with diagnostic tests.

Q: Are NIPT Tests Different?

Yes, NIPT tests differ from each other; they vary in terms of scope, technology, laboratory quality, and clinical performance. When choosing a test, attention should be paid not only to its name but also to the reliability of its content. Since the analysis methods and clinical performance data of the tests vary from laboratory to laboratory, how reliable they are for which conditions should be evaluated.

Q: What Do PPV and NPV Mean?

To understand how reliable NIPT results are, it is important to look not only at the positive/negative result but also at the PPV and NPV values. PPV (Positive Predictive Value) indicates the probability that the baby actually has the disease when the test is positive. NPV (Negative Predictive Value) indicates the probability that the baby actually does not have the disease when the test is negative.

Q: Scope in NIPT Tests

NIPT tests are offered at different levels depending on their scope. Basic NIPT mainly focuses on Trisomy 21, 18, and 13 conditions. Extended NIPT covers sex chromosome abnormalities and some additional evaluations in addition to basic trisomies. Advanced comprehensive NIPT can offer much broader screening options such as microdeletion syndromes, deletions/duplications, rare autosomal aneuploidies, and some hereditary diseases.

Q: NIPT vs Conventional Screening

Although both are screening tests that assess the risk of chromosomal diseases in pregnancy, their working methods are different. NIPT offers a much more sensitive, targeted, and highly accurate evaluation by directly examining the cell-free fetal DNA in the mother's blood. Conventional screening tests, on the other hand, are based on biochemical markers and ultrasound findings, and their accuracy rates are lower.

Q: Why is NIPT Preferred?

NIPT is performed to safely and early evaluate the risk of the baby carrying certain genetic and chromosomal diseases during pregnancy. The fact that the procedure is performed only with blood taken from the mother, and that it is non-invasive, meaning it does not cause any harm to the baby, is one of the most important reasons for preference. It has a high accuracy rate, especially in Trisomy 21, 18, and 13 diseases.

What is NIPT?

NIPT (Non-Invasive Prenatal Test) is an advanced prenatal screening test based on the examination of cell-free fetal DNA circulating in a blood sample taken from the mother during pregnancy.

Since it does not require direct intervention to the baby, it is non-invasive and therefore different from procedures such as amniocentesis.

Important note: NIPT is a screening test; it is not a definitive diagnostic test.

When is it Performed?

The NIPT test can usually be performed starting from the 10th week of pregnancy. After this period, a sufficient amount of fetal DNA is expected to be present in the mother's blood.

A simple blood draw from the mother is sufficient for the test. No special preparation or fasting is required.

Why is NIPT Preferred?

It is performed during pregnancy to help assess the baby's risk for certain chromosomal and genetic conditions early and reliably.

Performed from maternal blood
Does not harm the baby

What is Down Syndrome?

Down syndrome is a genetic difference that occurs when there is an extra copy of chromosome 21 in the baby's cells (Trisomy 21).

It is the most common type and can be screened with high accuracy using the NIPT test.

What is the Difference Between NIPT and Combined/Quad Screening Tests?

Although they are used for the same purpose, their working principles and accuracy rates are quite different.

Combined / Quad Screening

It is the conventional method.
Risk is calculated using biochemical markers in the mother's blood and ultrasound findings.
Its accuracy rate is lower than NIPT.
It may produce more false positive (misleadingly risky) results.
Sensitivity rate is approximately 80–85%, while the false positive rate is approximately 5%.

NIPT (Cell-free DNA Test)

It is a new generation method.
The cell-free fetal DNA (DNA belonging to the baby) in the mother's blood is directly analyzed.
It provides much higher accuracy, especially for Trisomy 21, 18, and 13.
It is a more advanced, targeted, and sensitive screening method.
Sensitivity rate is above 99%, while the false positive rate is below 0.1%.

Are NIPT Tests the Same? What Should Be Considered?

No, NIPT tests differ from one another. Scope, technology, laboratory quality, and test failure rate may vary.

Scope and Performance

The diseases the test can screen for and scientific performance data such as PPV/NPV are important.

Technology

The analysis method and algorithms affect the reliability of the test even at low fetal DNA rates.

Test Failure Rate

The "no-result" situation due to reasons such as low fetal DNA. Tests with low failure rates should be preferred.

Accreditation and Counseling

ISO standards and the provision of expert genetic counseling support, especially in suspicious cases, are critical.

Top NIPT Tests Ranking

An informative comparison prepared according to scope and published performance data.

Rank	Test	Scope	Performance	Total	Brief Comment
1	PrenatalSafe Full Risk	50.0	43.8	93.8	It is one of the strongest tests in terms of scope and scientific performance.
2	PrenatalSafe Complete Plus	45.0	43.8	87.8	It ranks in the highest group with its wide scope, low test failure rate, and published performance data.
3	PrenatalSafe Karyo Plus	38.0	43.8	81.8	It stands out with strong PPV/NPV data while offering broad chromosomal evaluation.
4	PrenatalSafe Plus	33.0	43.8	76.8	It offers additional scope to basic trisomies and has strong performance data.
5	Ninalia Genomewide	35.0	40.5	75.5	Offers the advantage of genome-wide analysis.
6	PrenatalSafe 5 DiGeorge	29.0	43.8	72.8	It provides an advantage by adding DiGeorge/microdeletion evaluation to the basic NIPT scope.
7	Nifty Pro + Mono	42.0	26.6	68.7	Although its scope is wide, data gaps in some performance areas lower the total score.
8	PrenatalSafe 5	23.0	43.8	66.8	Although its scope is more limited, its scientific performance data is strong.
9	Veragene	29.0	25.3	54.3	Although it offers certain additional scopes, test failure rate and data gaps limit the score.
10	Panorama	30.0	22.6	52.6	Although it offers scope in some specific areas, T13 and microdeletion PPV values lower the total performance score.
11	Veracity	25.0	25.3	50.3	Although basic performance data is available, test failure rate and limited scope affect the score.
12	RapidNIPT	30.0	10.0	40.0	It covers certain areas in terms of scope; however, the PPV/NPV data being N/A lowers the performance score.
13	NIPT 24	30.0	6.0	36.0	Although scope information is available, it receives a low score because scientific performance data has not been shared.
14	BabySec	30.0	0.0	30.0	Although scope information is available, no scientific performance score has been given because performance data is N/A.

Note: This scoring does not replace clinical decision-making; it is an informative comparison prepared according to the scope and published performance data of the tests. The data has been evaluated using artificial intelligence.

NIPT Tests Comparison

Detailed scientific analysis of popular NIPT tests frequently preferred in Cyprus and worldwide.

NIPT	PrenatalSafe 5	PrenatalSafe 5 DiGeorge	PrenatalSafe Plus	Ninalia Genomewide	PrenatalSafe Karyo Plus	PrenatalSafe Complete Plus	PrenatalSafe Full Risk	Veracity	Veragene	Nifty Pro + Mono	BabySec	NIPT 24	RapidNIPT	Panorama
Test Content
Test Origin	Italy	Italy	Italy	France	Italy	Italy	Italy	South Cyprus	South Cyprus	China	Turkey	Turkey	Turkey	USA
Common Trisomies: T21	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅
Common Trisomies: T18	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅
Common Trisomies: T13	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅
Common Trisomies: X/Y	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅
Other Trisomies: T9 & T16			✅	✅	✅	✅	✅			✅	✅	✅	✅
All Other Chromosomes				✅	✅	✅	✅			✅	✅	✅	✅
Microdeletion Syndromes		✅	✅		✅	✅	✅	✅	✅	✅	✅			✅
Single Gene Diseases						✅	✅			✅
Fetal Sex	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅	✅
Carrier Panel							✅		✅
Rh Safe	✅	✅	✅		✅	✅	✅							✅
ISO 15189 Accreditation	✅	✅	✅	✅	✅	✅	✅
Scientific Performance
Test Failure Rate / No Result	0.1%	0.1%	0.1%	0.1%	0.1%	0.1%	0.1%	6%	6%	0.1%	N/A	0.73%	0.1%	3.8%
T21 PPV/NPV (95% CI)	99.32/100	99.32/100	99.32/100	96.8/99.99	99.32/100	99.32/100	99.32/100	96.6/99.99	96.6/99.99	92.19/99.9	N/A	N/A	N/A	91/99.9
T18 PPV/NPV (95% CI)	98.94/100	98.94/100	98.94/100	86.3/99.99	98.94/100	98.94/100	98.94/100	92.6/99.99	92.68/99.99	76.6/100	N/A	N/A	N/A	93/99.9
T13 PPV/NPV (95% CI)	82.22/100	82.22/100	82.22/100	79.77/99.99	82.22/100	82.22/100	82.22/100	86.67/100	86.67/100	83.33/100	N/A	N/A	N/A	38/99.9
Sex Chromosome Aneuploidies PPV/NPV (95% CI)	90.17/100	90.17/100	90.17/100	N/A	90.17/100	90.17/100	90.17/100	84.00 / 99.99	84.00 / 99.99	N/A	N/A	N/A	N/A	89/N/A
Segmental Abnormalities (>7 Mb) PPV/NPV (95% CI)	55.56/100	55.56/100	55.56/100	NA	55.56/100	55.56/100	55.56/100	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Microdeletions / Segmental Abnormalities (<7 Mb) PPV/NPV (95% CI)	71.43/100	71.43/100	71.43/100		71.43/100	71.43/100	71.43/100	*N/A	*N/A	NA	N/A			10.2/99.9

*DiGeorge PPV/NPV (95% CI) 88.89/100 for Veracity, other 3 microdeletions no data.

What Do PPV and NPV Mean? Why Are They Important?

When interpreting NIPT results, knowing only the "positive" or "negative" result is not enough. It is also important to understand how reliable the result is.

PPV

Positive Predictive Value (PPV)

It is the probability that the baby actually has that condition when the test is positive.

So if the risk was high in the test, it shows how strongly this result actually supports the disease. PPV can vary according to the prevalence of the disease in the population and the risk level of the pregnancy.

NPV

Negative Predictive Value (NPV)

It is the probability that the baby actually does not have that condition when the test is negative.

So it shows how reassuring the result is in low-risk results.

Frequently Asked Questions

NIPT (Non-Invasive Prenatal Test) is an advanced screening test that analyzes cell-free fetal DNA in a blood sample taken from the mother. Since there is no direct intervention to the baby, it is non-invasive and different from amniocentesis. The test can be performed from the 10th week of pregnancy without requiring any special preparation or fasting. NIPT is a screening test; high-risk results must be confirmed with diagnostic tests. Learn more

Down syndrome is a genetic difference that occurs when there is an extra copy of chromosome 21 in the baby's cells (Trisomy 21). This condition can affect the baby's physical appearance, growth, and learning process, and can cause some health problems. Increased maternal age can increase the risk, but babies with Down syndrome can be seen in pregnancies of all ages. The NIPT test is a reliable screening method that can assess the risk of Down syndrome in the early stages of pregnancy with high accuracy. Learn more

Yes, NIPT tests differ from each other; they vary in terms of scope, technology, laboratory quality, and clinical performance. When choosing a test, attention should be paid not only to its name but also to the reliability of its content. Since the analysis methods and clinical performance data of the tests vary from laboratory to laboratory, how reliable they are for which conditions should be evaluated. Learn more

To understand how reliable NIPT results are, it is important to look not only at the positive/negative result but also at the PPV and NPV values. PPV (Positive Predictive Value) indicates the probability that the baby actually has the disease when the test is positive. NPV (Negative Predictive Value) indicates the probability that the baby actually does not have the disease when the test is negative. Learn more

NIPT tests are offered at different levels depending on their scope. Basic NIPT mainly focuses on Trisomy 21, 18, and 13 conditions. Extended NIPT covers sex chromosome abnormalities and some additional evaluations in addition to basic trisomies. Advanced comprehensive NIPT can offer much broader screening options such as microdeletion syndromes, deletions/duplications, rare autosomal aneuploidies, and some hereditary diseases. Learn more

Although both are screening tests that assess the risk of chromosomal diseases in pregnancy, their working methods are different. NIPT offers a much more sensitive, targeted, and highly accurate evaluation by directly examining the cell-free fetal DNA in the mother's blood. Conventional screening tests, on the other hand, are based on biochemical markers and ultrasound findings, and their accuracy rates are lower. Learn more

NIPT is performed to safely and early evaluate the risk of the baby carrying certain genetic and chromosomal diseases during pregnancy. The fact that the procedure is performed only with blood taken from the mother, and that it is non-invasive, meaning it does not cause any harm to the baby, is one of the most important reasons for preference. It has a high accuracy rate, especially in Trisomy 21, 18, and 13 diseases. Learn more

Our Contact Information

You can use the form on the right to get detailed information about the tests or to schedule an appointment.

Working Hours

Monday-Friday: 08:00 - 18:00
Saturday: 08:00 - 14:00

Your Name & Surname

Your Phone Number

Your Email Address

Pregnancy Week

City

Test of Interest (Optional)

Your Message / Question

When you submit the form, feedback will be provided for informational purposes. Your information is kept confidential.

The Most Reliable Step For Your Baby's Health